ICAAC2014 Online
本日もManagement of Endocarditis: An Update
・βラクタム剤を加えるとVCMやDaptomycinの効果↑
＃：See-Saw 効果
・βラクタム剤を加えるとVCMやDaptomycinのMICが下がる！！
Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, Yeaman MR, Bayer AS.
Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2009 Jun;53(6):2312-8.
PMID: 19332678
＃：Daptomycin ＋ βラクタム
・まず黄色ブドウ球菌用ペニシリンはMRSAに対する免疫を賦活
Sakoulas G, Okumura CY, Thienphrapa W
Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus.
J Mol Med (Berl). 2014 Feb;92(2):139-49.
PMID: 24297496
・黄色ブドウ球菌用ペニシリンとDaptomycinを併用すると良い
・仕組みはペニシリンにより、Daptomycinの細胞膜結合が進む
![]()
Dhand A, Bayer AS, Pogliano J, Yang SJ
Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding.
Clin Infect Dis. 2011 Jul 15;53(2):158-63.
PMID: 21690622
・CeftarolineとDaptomycinの併用も同様
Werth BJ, Sakoulas G, Rose WE
Ceftaroline increases membrane binding and enhances the activity of daptomycin against daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus in a pharmacokinetic/pharmacodynamic model.
Antimicrob Agents Chemother. 2013 Jan;57(1):66-73.
PMID: 23070161
・Ceftaroline、OxacillinとVancomycinの併用も
Werth BJ, Vidaillac C, Murray KP, Newton KL
Novel combinations of vancomycin plus ceftaroline or oxacillin against methicillin-resistant vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA.
Antimicrob Agents Chemother. 2013 May;57(5):2376-9.
PMID: 23422917
＃：Vancomycin ＋ βラクタム
・VCMも同様にβラクタム剤の併用で良いみたい。
Dilworth TJ, Ibrahim O, Hall P, Sliwinski J
β-Lactams enhance vancomycin activity against methicillin-resistant Staphylococcus aureus bacteremia compared to vancomycin alone.
Antimicrob Agents Chemother. 2014;58(1):102-9.
PMID: 24145519
＃：感染症専門医が加わると予後が改善！！
当然ですね。本田仁先生の論文もどぞ
![]()
本日もManagement of Endocarditis: An Update
・βラクタム剤を加えるとVCMやDaptomycinの効果↑
＃：See-Saw 効果
・βラクタム剤を加えるとVCMやDaptomycinのMICが下がる！！
Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, Yeaman MR, Bayer AS.
Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2009 Jun;53(6):2312-8.
PMID: 19332678
＃：Daptomycin ＋ βラクタム
・まず黄色ブドウ球菌用ペニシリンはMRSAに対する免疫を賦活
Sakoulas G, Okumura CY, Thienphrapa W
Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus.
J Mol Med (Berl). 2014 Feb;92(2):139-49.
PMID: 24297496
・黄色ブドウ球菌用ペニシリンとDaptomycinを併用すると良い
・仕組みはペニシリンにより、Daptomycinの細胞膜結合が進む
Dhand A, Bayer AS, Pogliano J, Yang SJ
Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding.
Clin Infect Dis. 2011 Jul 15;53(2):158-63.
PMID: 21690622
・CeftarolineとDaptomycinの併用も同様
Werth BJ, Sakoulas G, Rose WE
Ceftaroline increases membrane binding and enhances the activity of daptomycin against daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus in a pharmacokinetic/pharmacodynamic model.
Antimicrob Agents Chemother. 2013 Jan;57(1):66-73.
PMID: 23070161
・Ceftaroline、OxacillinとVancomycinの併用も
Werth BJ, Vidaillac C, Murray KP, Newton KL
Novel combinations of vancomycin plus ceftaroline or oxacillin against methicillin-resistant vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA.
Antimicrob Agents Chemother. 2013 May;57(5):2376-9.
PMID: 23422917
＃：Vancomycin ＋ βラクタム
・VCMも同様にβラクタム剤の併用で良いみたい。
Dilworth TJ, Ibrahim O, Hall P, Sliwinski J
β-Lactams enhance vancomycin activity against methicillin-resistant Staphylococcus aureus bacteremia compared to vancomycin alone.
Antimicrob Agents Chemother. 2014;58(1):102-9.
PMID: 24145519
＃：感染症専門医が加わると予後が改善！！
当然ですね。本田仁先生の論文もどぞ
