以前からポリオウイルスにしても、無菌性髄膜炎の原因としてのエンテロウイルスなどにしても、腸管系が好きなウイルスは神経も好きだな・・という編集長の印象が更にIntensifyされる事になりました。
HEVは勿論、肝炎で有名（特に妊婦や他の免疫不全状態で・・）でしたが、他の病態（腎障害、急性膵炎、造血器疾患、そして多種の神経障害）ともAssociateする事は知られて居ました。
何と、ここにきて幹細胞由来の神経細胞を直接、感染する事が判明。更にγインターフェロンやRibavirinが有効・・といった事が判明してきたようです。
だから感染症は目が離せない。そして面白い。
詳細は以下をどぞ
Hepatitis E Virus Infects Neurons and Brains
X Zhou et al. J Infect Dis 215 (8), 1197-1206. 2017 Apr 15. more
Abstract
Hepatitis E virus (HEV), as a hepatotropic virus, is supposed to exclusively infect the liver and only cause hepatitis. However, a broad range of extrahepatic manifestations (in particular, idiopathic neurological disorders) have been recently reported in association with its infection. In this study, we have demonstrated that various human neural cell lines (embryonic stem cell-derived neural lineage cells) induced pluripotent stem cell-derived human neurons and primary mouse neurons are highly susceptible to HEV infection. Treatment with interferon-α or ribavirin, the off-label antiviral drugs for chronic hepatitis E, exerted potent antiviral activities against HEV infection in neural cells. More importantly, in mice and monkey peripherally inoculated with HEV particles, viral RNA and protein were detected in brain tissues. Finally, patients with HEV-associated neurological disorders shed the virus into cerebrospinal fluid, indicating a direct infection of their nervous system. Thus, HEV is neurotropic in vitro, and in mice, monkeys, and possibly humans. These results challenge the dogma of HEV as a pure hepatotropic virus and suggest that HEV infection should be considered in the differential diagnosis of idiopathic neurological disorders.
PubMed: 28199701
編集長：冷麺をあまり辛くしないように・（笑）
HEVは勿論、肝炎で有名（特に妊婦や他の免疫不全状態で・・）でしたが、他の病態（腎障害、急性膵炎、造血器疾患、そして多種の神経障害）ともAssociateする事は知られて居ました。
何と、ここにきて幹細胞由来の神経細胞を直接、感染する事が判明。更にγインターフェロンやRibavirinが有効・・といった事が判明してきたようです。
だから感染症は目が離せない。そして面白い。
詳細は以下をどぞ
Hepatitis E Virus Infects Neurons and Brains
X Zhou et al. J Infect Dis 215 (8), 1197-1206. 2017 Apr 15. more
Abstract
Hepatitis E virus (HEV), as a hepatotropic virus, is supposed to exclusively infect the liver and only cause hepatitis. However, a broad range of extrahepatic manifestations (in particular, idiopathic neurological disorders) have been recently reported in association with its infection. In this study, we have demonstrated that various human neural cell lines (embryonic stem cell-derived neural lineage cells) induced pluripotent stem cell-derived human neurons and primary mouse neurons are highly susceptible to HEV infection. Treatment with interferon-α or ribavirin, the off-label antiviral drugs for chronic hepatitis E, exerted potent antiviral activities against HEV infection in neural cells. More importantly, in mice and monkey peripherally inoculated with HEV particles, viral RNA and protein were detected in brain tissues. Finally, patients with HEV-associated neurological disorders shed the virus into cerebrospinal fluid, indicating a direct infection of their nervous system. Thus, HEV is neurotropic in vitro, and in mice, monkeys, and possibly humans. These results challenge the dogma of HEV as a pure hepatotropic virus and suggest that HEV infection should be considered in the differential diagnosis of idiopathic neurological disorders.
PubMed: 28199701
編集長：冷麺をあまり辛くしないように・（笑）